Sarah Goh

Sarah Goh

Professor of Chemistry

413-597-4223
Bronfman Science Center Rm 326
At Williams since 2004
Lab: 324/325 BSC, (413) 597-3027

Education

B.S. University of Michigan (1996)
M.S. University of Massachusetts, Amherst, Polymer Science & Engineering (1998)
Ph.D. University of California, Berkeley, Organic & Polymer Chemistry (2004)

Areas of Expertise

To investigate non-covalent assemblies based on biological system through: Development of self-assembled hydrogels by integrating synthetic polymer and protein-mimetic components, resulting in materials with tunable properties and function. Advancement of enzymatic poymerization methodologies for the preparation of functional polymers by exploring active site geometries through genetic engineering. Evaluation of protein- and polysaccharide-based platforms for the targeted placement of active nono-catalyst centers in order to control macroscale function and architecure of these assemblies.

Courses

Note: courses in gray are not offered this academic year.

CHEM 344 T(S)

Physical Organic Chemistry

CHEM 348(F)

Polymer Chemistry

Scholarship/Creative Work

Goh, S. L.; Murthy, N.; Xu, M.; Frechet, J. M. J. "Crosslinked Microparticles as Carriers for the Delivery of Plasmid DNA for Vaccine Development" submitted. Goh, S. L.; Dande, P.; Francis, M. B.; Frechet, J. M. J. "Solid-Phase Synthesis of Functionalized DNA-Dendron Conjugates as Building Blocks for Self-Assembled Dendrimers" in preparation. Goh, S. L.; Murthy, N. Xu M..; Schuck, S. M.; Lau, L.; Dubber, M.; Frechet, J. M. J. "Encapsulation of Bioactive Molecules in Crosslinked Microgels" Polym. Mat. Sci. Eng. 2003, 88, 222-223; highlighted in Chem. Britain 2003, 39, 17. Williams, S. C.; Goh, S. L.; Micheel, C. M.; Zanchet, D.; Parak W. J.; Alivisatos, A. P. "Producing Discrete and More Complex Nanoparticle Arrangements using Asymmetric Branched DNA Trimers" Abstr. Am. Chem. Soc., Div. Phys. Chem. 2003, 225, 56. Frechet, J. M. J.; Murthy, N.; Dubber, M.; Goh, S.; Schuck, S.; Xu, M. "Synthetic macromolecules in therapeutics: Design, synthesis, and functional testing of polymers for protein and DNA transport and delivery" Abstr. Am. Chem. Soc., Div. Polym. Mat. Sci. Eng. 2003, 225, 39. Goh, S. L.; Francis, M. B.; Frechet, J. M. J. "Self-assembled oligonucleotide-polyester dendrimers" Chem. Commun. 2002, 24, 2954-2955. Micheel, C. M.; Jun, Y. W.; Williams, S. C.; Goh, S. L.; Zanchet, D.; Parak, W. J.; Gerion, D.; Pellegrino, T.; Alivisatos, A. P. "Novel characterization techniques for recent nanocrystal molecules" Abstr. Am. Chem. Soc., Div. Phys. Chem. 2002, 224, 248. Francis, M. B.; Goh, S. L.; Dande, P.; De Jesus, O. L. P.; Frechet, J. M. J. "DNA-Dendrimer Conjugates for Drug Delivery" Polym. Mat. Sci. Eng. 2001, 84, 12-13. Frechet, J. M. J.; Goh, S. L.; Franics, M. B. "Self-Assembly of Dendritic Light Harvesting Systems" Polym. Mat. Sci. Eng. 2001, 84, 710-711. Frechet, J. M. J.; Goh, S. L.; Franics, M. B. "Self-Assembly of Dendritic Light Harvesting Systems" Polym. Mat. Sci. Eng. 2001, 84, 710-711.

Previous Courses Taught

  • 156: Organic Chemistry: Introductory Level
  • 251: Organic Chemistry: Intermediate Level
  • 344: Physical Organic Chemistry

Current Committees

  • Faculty Review Panel

Summer 2006 Research Students

  • Katherine Ackerman '08
  • Caroline Gross '08
  • William McClain '09
  • Nicholas Reynolds '08

Honors Research Students

  • William Parsons '07
  • Andrew Platt '07
  • Mary Beth Anzovino '06
  • Surekha Garjia '06
  • Katherine Rutledge '05
  • David Thome '05