Sarah Goh

Sarah Goh

Chair and Professor of Chemistry

413-597-4223
Hopper Science Center Rm 124
At Williams since 2004

Lab: 102 HSB, (413) 597-3027

Education

B.S. University of Michigan (1996)
M.S. University of Massachusetts, Amherst, Polymer Science & Engineering (1998)
Ph.D. University of California, Berkeley, Organic & Polymer Chemistry (2004)

Areas of Expertise

To investigate non-covalent assemblies based on biological system through:

Development of self-assembled hydrogels by integrating synthetic polymer and protein-mimetic components, resulting in materials with tunable properties and function.

Advancement of enzymatic poymerization methodologies for the preparation of functional polymers by exploring active site geometries through genetic engineering.

Evaluation of protein- and polysaccharide-based platforms for the targeted placement of active nono-catalyst centers in order to control macroscale function and architecure of these assemblies.

Scholarship/Creative Work

* indicates undergraduate authors

Goh, S. L. Polymer chemistry in an undergraduate curriculum. ACS Symp. Ser. 2014, 1151, 113-127.

Parsons*, W. H.; Hong*, L.; Markgraf, J. H.; Goh, S. L. Hammett correlations of benzhydrylium cations. Chem. Educator, 2012, 17, 53-56.

Hwang*, E. E.; Wilson-Hill*, T. R.; Anh*, J. W.; Platt, A. P.; Rutledge, K. E.; Goh, S. L. Self-assembly of di- and triblock PEG-pentavaline amphiphiles. J. Polym. Sci. A: Polym. Chem., 2011, 49, 871-878.

Chiu*, K.; Agoubi*, L. L.; Lee*, I.; Limpar*; M. T.; Lowe*, J. W., Jr.; Goh, S. L. Effects of polymer molecular weight on the size, activity, and stability of PEG-functionalized trypsin. Biomacromolecules, 2010, 11, 3688-3692.

Goh, S. L.; Platt*, A. P.; Rutledge*, K. E.; Lee*, I. Synthesis and aggregation of poly(valine)-poly(ethylene glycol) block copolymers. J. Polym. Sci. A: Polym. Chem. 2008, 46, 5381-5389.

Standley, S. M.; Mende, I.; Goh, S. L.; Kwon, Y. J.; Beaudette, T. T.; Engleman, E. G.; Fréchet , J. M. J. Incorporation of CpG oligonucleotide ligand into protein-loaded particle vaccines promotes antigen-specific CD8 T-cell immunity. Bioconjugate Chem. 2007, 18, 77-83.

Kwon, Y. J.; Standley, S. M.; Goh, S. L.; Fréchet, J. M. J. Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles. J. Controlled Release 2005, 105, 199-212.

Claridge, S. A.; Goh, S. L.; Williams, S. C.; Micheel, C. M.; Fréchet, J. M. J.; Alivisatos, A. P. “Directed assembly of gold nanocrystals using branched DNA scaffolds” Chem. Mater. 2005, 17, 1628-1635.

Goh, S. L.; Murthy, N.; Xu, M.; Fréchet, J. M. J. Crosslinked microparticles as carriers for the delivery of plasmid DNA for vaccine development. Bioconjugate Chem. 2004, 15, 467-474.

Goh, S. L.; Francis, M. B.; Fréchet, J. M. J. Self-assembled oligonucleotide-polyester dendrimers. Chem. Commun. 2002, 24, 2954-2955.

Laudise, R. A.; Bridenbaugh, P. M.; Kloc, C.; Jouppi, S. L. Organo-thermal crystal growth of alpha 6 thiophene. J. Crystal Growth 1997, 178, 585-592.

Blohowiak, K. Y.; Treadwell, D. R.; Mueller, B. L.; Hoppe, M. L.; Jouppi, S., Pansal, P.; Chew, K. W.; Scotto, C. L. S.; Babonneau, F.; Kampf, J.; Laine, R. M. SiO2 as a Starting Material for the Synthesis of Pentacoordinate Silicon Complexes. I. Chem. Mater. 1994, 6, 2177-2192.

Previous Courses Taught

  • 151: Introductory Chemistry
  • 153: Concepts in Chemistry
  • 156: Organic Chemistry: Introductory Level
  • 251: Organic Chemistry: Intermediate Level
  • 255: Organic Chemistry: Intermediate Level-Special Laboratory Section
  • 344T: Physical Organic Chemistry
  • 348: Polymer Chemistry

2021-22 Research Students

  • Maya I. Huffman ’22
  • Marcelo M. Mazariego ’22
  • Taylor McClennan ’22
  • Kevin Garcia Rios ’22
  • Caroline Broude ’23
  • Lexi Poindexter ’23
  • Steven Lee ’24
  • Angelica Pena ’24
  • Sara López-Quintana ’25
  • Addison Zou ’25

Honors Research Students

  • Maya I. Huffman ’22
  • Marcelo M. Mazariego ’22
  • Taylor McClennan ’22
  • Kevin Garcia Rios ’22
  • Vanessa Quevedo Barrios ’21
  • Julie Ha ‘20
  • Justin Ho ‘20
  • Luke L. Cai ’19
  • Alexi M. McAdams ’18
  • Hannah G. Cole ’17
  • Emily A. Hoyt ’17
  • Hanson D. Koota ‘17
  • Jessica O’Brien ’16
  • Luxi Qiao ’16
  • Dylan M. Barber ’15
  • Denise Park ’15
  • Todd A. Brenner ’14
  • Julia H. Nguyen, ’14
  • Bianca A. Ulloa ’14
  • Lauren A. Agoubi ‘13
  • Alexander N. Lou ‘13
  • Michelle M. McRae ’12
  • Matthew N. Zhou ’12
  • Colin A. Platt ’11
  • Charles A. Seipp ‘11
  • Karen Chiu ’10
  • Iris Lee, ’09
  • James W. Lowe Jr. ’09
  • Roger Luo ’08
  • William Parsons ’07
  • Andrew Platt ’07
  • Mary Beth Anzovino ’06
  • Surekha Garjia ’06
  • Katherine Rutledge ’05